The Best Nootropics for Depression

Depression at its best can be irritating; at its worst it can be debilitating. Millions of people in this country suffer from depression, feeling they have little recourse but to take hard-core prescription drugs with many different and sometimes worse side effects than the depression itself. There are other and more natural ways of controlling your depression and while you should take to your doctor or other health care professional before stopping or slowing down the drugs for your depression, you can still investigate your other options. Nootropics are natural substances that work with the chemicals and systems in your brain to balance everything out and inevitably get you free from depression.

Natural ways of alleviating depressive symptoms have been proven to help in even some of the worst cases, but you shouldn’t just use nootropics alone. Studies have shown that other factors have an effect on depression and should be looked at as well. These include:

  • A regular exercise routine
  • A healthy diet
  • Having good social supports
  • Seeking counselling or other forms of therapy
  • Mindfulness
  • Challenging yourself to think positive and to do the things depression is stopping you from doing

While these ideas are definitely helpful in relieving depression, again they don’t work alone either. Nootropics can be used with all of these to give you a complete regime for fighting depression.

What are the best nootropics for depression?


Typically used as a cognitive enhancer and energy booster, Noopept is a nootropic that can be taken regularly to help relieve the symptoms of depression. You will already feel more alert, focused and calm, while having increased energy while taking Noopept, but along with that, your feelings of lowness may be boosted and a general feeling of well-being may be there instead. Noopept is also a neuro-protective, which means that it protects the brain and its symptoms and may also reverse the damage that has been done to the brain by stress, medications, trauma and other unhealthy actions. In doing so, Noopept has been shown to increase neurotransmitter connections in the brain, which means that as you take it, your brain will get better and better. Rather than temporarily helping you get rid of depression, it can actually be a long-term solution due to its repairing effects.

{*copy* Nootropics help to relieve depression symptoms so you can live your life as you should be.}


Typically used as an anti-anxiety nootropic, this supplement also treats insomnia and even PTSD, and its effects on depression are also well-known. Phenibut is a derivative of GABA, which is a neurotransmitter in the brain that when levels of it are low, will cause some mood-related disorders. Boosting GABA can definitely have anti-depressive effects. Some users have likened Phenibut to “rose-coloured glasses” letting them see the world in a more positive light. Taken with a stimulant like caffeine, the effects of Phenibut will be heightened and you’ll see yourself having more energy as well.


Serotonin is often implicated in mood disorders and depression, especially when the levels are too low. Many prescription drugs on the market are used to increase serotonin levels in the brain to relieve depression. These SSRIs do have myriad side effects and withdrawal can be nasty, which is why nootropics may be better solution for depression. There are nootropics that increase serotonin levels and 5-HTP is one of them. 5-HTP is used to treat a number of ailments along with depression, including anxiety, migraines, PMS and ADHD. All of these ailments may have a co-relation with low levels of serotonin in the brain, although each has its own complex make-up. 5-HTP can also have the added benefit of reducing appetite, which may be helpful in those who are depressed and have significant weight issues either as the cause of depression or because of depression.


Not for the uninformed, you should definitely speak to a healthcare provider before starting on an Adrafinil regime. It can have an effect on your liver and have some potentially unwanted side effects, so you’ll need to decide if the benefits outweigh the risks. If you’ve tried some of the “lighter” nootropics and not had the great effects on your depression that you’d hope for, Adrafinil might be your next best bet. It works by balancing out your serotonin and dopamine levels, which you already know is implicated in causing depressive symptoms when levels are off. It can also give you a huge boost of energy, which can impact your daily productiveness even if it doesn’t completely eliminate your depression.

Omega-3 fatty acids

While these are not typically a nootropic, they do work with nootropics to alleviate depressive symptoms. Eating foods rich in Omega 3s is helpful, and these include fatty fish, nuts, flaxseeds, soybeans, vegetable oils and more. Supplementation of Omega-3 is recommended for anyone who doesn’t regularly include these foods in their diet or who might have depressive symptoms.


Deficiencies in B vitamins definitely play a role in depression. While this factor is not alone in contributing to your entire depression representation, supplementing with B vitamins, along with the nootropics mentioned above is a good idea. Again, you can get B vitamins from foods like citrus fruits, green leafy vegetables, chicken and eggs, taking a Vitamin B supplement can be useful when you are trying to control your depression.

Curing or relieving yourself of depression takes a bit of work and not all methods work for all people. Trying nootropics along with other methods known to lessen depressive symptoms can be a great form of attack before going the prescriptive route. Your doctor should be able to help you make the right choice for your body type, age and sex.